The present article illustrates the experimental results of investigation of antiradical defense system state at conditions of crown-ethers action upon the organism of warm-blooded animals. The research program used sub-acute toxicological experiment on sexually mature white male rats of WAG population (body mass - 180-220 g). The animals were administered with water emulsion of investigated crown-ethers (12-crown-4, 15-crown-5, and 18-crown-6) in 1/100 and 1/1000 LD50 daily, within 30 days

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... rally. The animals of the control group were given water at the same conditions. On the 30th day of the experiment the rats of all groups were anesthetized by sodium thiopental (50 mg/kg) and slaughtered by decapitation with the Guillotine knife. Oxidantantioxidant interaction was evaluated using the following indexes: SH-groups, vitamin C, vitamin E contents; haptoglobin, MDA, and DC concentrations; ceruloplasmin, catalase, peroxidase, SOD, GP activities. All crown-ethers 1/1000 LD50 (subtoxic dose) increased blood serum contents of DC by 80.1; 75.4; 70.2% and MDA 108.9; 130.8; 82.4% for 12-crown-4, 15-crown-5, 18-crown-6, respectively. Their action also resulted in enhancing the activity of investigated antioxidant system enzymes – blood catalase (by 35% on average), blood peroxidase (by 80% on average), blood GP (by 60% on average) and blood SOD (by 40% on average). Crown-ethers significantly increased concentrations of serum ceruloplasmin (by 85% on average) and haptoglobin (by 82% on average). The concentration of the main antioxidant peptide glutathione (reduced form) was higher in blood of the experimental rats, whereas the general contents of SH-groups became diminished. The contents of adrenal gland vitamin C got increased (by more than 40%) in the action of crown-ethers on the background of decreasing in serum vitamin E concentration. The action of 12-crown-4, 15-crown-5 and 18-crown-6 1/100 LD50 resulted in the pronounced increase in blood serum contents of DC by 152; 138; 144% and MDA by 178; 162; 154%, respect [...]