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An autoimmune diathesis has been proposed in Tourette syndrome (TS) and related neuropsychiatric disorders such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism and anorexia nervosa. Environmental triggers including infection and xenobiotics are hypothesized to lead to the production of brain-directed autoantibodies in a subset of genetically susceptible individuals. Although much work has focused on Group A Streptococcus (GAS), the role of this commondoi:10.1016/j.neubiorev.2013.01.007 pmid:23313649 pmcid:PMC4054816 fatcat:jf7kpv5fsrghtfl4qgjzulvpki