Comparison of Linear Accelerator and Helical Tomotherapy Plans for Glioblastoma Multiforme Patients

Timur Koca, Hamit Basaran, Duygu Sezen, Sibel Karaca, Yasemin Ors, Deniz Arslan, Aysen Aydin
2014 Asian Pacific Journal of Cancer Prevention  
Despite advances in radiotherapy, overall survival of glioblastoma multiforme (GBM) patients is still poor. Moreover dosimetrical analyses with these newer treatment methods are insufficient. The current study is aimed to compare intensity modulated radiation therapy (IMRT) linear accelerator (linac) and helical tomotherapy (HT) treatment plans for patients with prognostic aggressive brain tumors. Material and Methods: A total of 20 GBM patient plans were prospectively evaluated in both linac
more » ... d HT planning systems. Plans are compared with respect to homogenity index, conformity index and organs at risk (OAR) sparing effects of the treatments. Results: Both treatment plans provided good results that can be applied to GBM patients but it was concluded that if the critical organs with relatively lower dose constraints are closer to the target region, HT for radiotherapeutical application could be preferred. Conclusion: Tomotherapy plans were superior to linear accelerator plans from the aspect of OAR sparing with slightly broader low dose ranges over the healthy tissues. In case a clinic has both of these IMRT systems, employment of HT is recommended based on the observed results and future re-irradiation strategies must be considered.
doi:10.7314/apjcp.2014.15.18.7811 fatcat:cpvcjvhxyzbudfmg6oyllrqgtm