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Stem Cell Reports
Crohn's disease (CD) is characterized by the expansion of mesenteric fat, also known as "creeping fat." We explored the plasticity and immune properties of adipose-derived stem cells (ASCs) in the context of CD as potential key players in the development of creeping fat. Mesenteric CD-derived ASCs presented a more proliferative, inflammatory, invasive, and phagocytic phenotype than equivalent cells from healthy donors, irrespective of the clinical stage. Remarkably, ASCs from the subcutaneousdoi:10.1016/j.stemcr.2017.07.014 pmid:28966116 pmcid:PMC5639166 fatcat:x6m6whbqk5fwnlo2n3qiydden4