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MAPK and Hippo signaling pathways crosstalk via the RAF-1/MST-2 interaction in malignant melanoma
The aim of the present study was to expound on the interactions between the mitogen-activated protein kinase (MAPK) and Hippo pathway members, and to further elucidate the molecular mechanisms of melanoma tumorigenesis. Four melanoma cell lines (C32, HS695T, SK-MEL-28 and A375) were used in the present study. Western blotting was used to assess the expression levels of the MAPK and Hippo pathway effector proteins: rapidly accelerated fibrosarcoma-1 proto-oncogene, serine/threonine kinasedoi:10.3892/or.2017.5774 pmid:28677804 fatcat:eiophg42wre47ixur4kinb4zkm