Advances in Clinical Application of ctDNA Detection in NSCLC

Xiaochun Zhang
2018 Journal of Cancer Treatment and Diagnosis  
With high morbidity and mortality, lung cancer has become the leading cause of cancer-related death worldwide, of which 85% are non-small-cell lung cancer (NSCLC). Most patients present with advanced disease at diagnosis and 5-year survival rate is no more than 30% due to lack of appropriate screening and early detection. In spite of tissue samples, ctDNA (circulating tumor DNA) is also widely used for molecular profiling to guide the treatment of NSCLC for lots of advantages. This review
more » ... focuses on the clinical and investigational applications of ctDNA detection in facilitating the personalized therapy of NSCLC.
doi:10.29245/2578-2967/2018/2.1121 fatcat:u7uwjediw5dufof4gq3qzmizqm