Deep White Matter Pathologic Features in Watershed Regions

Liana G. Apostolova, Matthew White, Steven A. Moore, Patricia H. Davis
2005 Archives of Neurology  
Myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome typically manifests in adults younger than 40 years with encephalopathy, stroke-like episodes, and lactic acidosis. Magnetic resonance imaging (MRI) abnormalities typically involve the cortical gray and the adjacent subcortical white matter. Objective: To describe a 58-year-old woman diagnosed with MELAS who was initially seen with acute myopathy, cardiac ischemia, psychosis, and MRI changes in a watershed
more » ... ibution. Results: Initial MRI of the brain showed the characteristic parieto-occipital gray matter lesions involving the adjacent white matter. Follow-up MRI revealed striking
doi:10.1001/archneur.62.7.1154 pmid:16009776 fatcat:x7z2tdh5xzhznfmf6yd5zkwfia