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Enhancing the efficacy of breast adenocarcinoma tumor treatment using thalidomide and doxorubicin-containing nanomicelles under dual-frequency sonication
This study aimed to evaluate the effect of dual-frequency sonication in the presence of thalidomide angiogenesis inhibitor and nanomicelles containing doxorubicin on inhibiting the growth and angiogenesis of breast adenocarcinoma in BALB/c female mice. Sixty mice carrying the tumor were divided into 12 groups: (A) control, (B) 28 kHz and 3 MHz sonication, (C) thalidomide, (D) thalidomide and 28 kHz, (E) thalidomide and 3 MHz, (F) thalidomide and dual-frequency sonication, (G) doxorubicin, (H)doi:10.21203/rs.3.rs-1996852/v1 fatcat:bdkwh3d44ze33aqrd4ic5hyftq