Internet Archive Scholar

DNA polymerase epsilon (POLE) is differentially expressed in the lymph node and brain metastases of patients with metastatic breast cancer [post]

Shahan Mamoor
2020 unpublished

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (185.8 kB)
https://web.archive.org/web/20220522000411/https://files.osf.io/v1/resources/dhm8f/providers/osfstorage/5fdbef66f0df5405132ed042?action=download&direct&version=4

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL. The file type is application/pdf.

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the DNA polymerase epsilon, catalytic subunit, encoded by POLE was among the genes whose expression was most different in the brain and lymph node metastases of patients with metastatic breast cancer as
more » ... to primary tumors of the breast and normal breast tissues, respectively. POLE mRNA was present at higher quantities in brain metastatic tissues as compared to primary tumors of the breast. These data combined suggest some level of common origin for metastases that reside in the lymph nodes and colonize the brain.
doi:10.31219/osf.io/dhm8f fatcat:nr3dig6jdrgapoyxuiyma6vglm
Open Access
Citation

Shahan Mamoor. "DNA polymerase epsilon (POLE) is differentially expressed in the lymph node and brain metastases of patients with metastatic breast cancer." (2020)