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A new orally active oxidosqualene:lanosterol cyclase (OSLC) inhibitor (Ro48-8071; Morand, O. H. et al. (1997) J. Lipid Res. 38, 373-390) showed potent noncompetitive inhibition of bacterial squalene:hopene cyclase (SHC) from Alicyclobacillus acidocaldarius (IC 50 ) 9.0 nM, K I ) 6.6 nM) and OSLC (IC 50 ) 40 nM, K I ) 22 nM for homogeneous rat liver OSLC). A tritium-labeled isotopomer (18.8 Ci/mmol) of this nonterpenoid inhibitor, which possesses a benzophenone (BP) photophore, was chemicallydoi:10.1021/bi980366c pmid:9558310 fatcat:tkthrwuvebeonctfbesbkmfprm