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A Brief History of Protein Sorting Prediction
2019
The Protein Journal
Ever since the signal hypothesis was proposed in 1971, the exact nature of signal peptides has been a focus point of research. The prediction of signal peptides and protein subcellular location from amino acid sequences has been an important problem in bioinformatics since the dawn of this research field, involving many statistical and machine learning technologies. In this review, we provide a historical account of how position-weight matrices, artificial neural networks, hidden Markov models,
doi:10.1007/s10930-019-09838-3
pmid:31119599
pmcid:PMC6589146
fatcat:cufi3rynanfjxntr76b77lhfwq