Infiltrating Cell Profiles of Sarcoid Lesions in the Muscles and Peripheral Nerves: an Immunohistological Study

Yasutaka TAJIMA, Kazunori SHINPO, Yoshiko ITOH, Yasunori MITO, Fumio MORIWAKA, Kunio TASHIRO
1997 Internal medicine (Tokyo. 1992)  
In order to study the pathological mechanismsof neuromuscular sarcoidosis, wecarried out an immunohistochemicalinvestigation in five cases (five muscle specimens and two sural nerve specimens). Weevaluated the distribution of inflammatory mononuclearcells and major histocompatibility complex (MHC) antigen expressions. Our data showed a dominant infiltration of helper/ inducer T cells (CD4-T cells), suggesting the importance of cell-mediated immune responses in neuromuscular sarcoidosis.
more » ... arcoidosis. However, we could not identify the distinct distributional patterns of T cells as reported in sarcoid lymphadenitis. This result maybe attributed to the difference of the affected organs. Moreover, failure to detect class II antigens in the muscle fibers may imply the difference in pathogenic mechanism between neuromuscular sarcoidosis and other inflammatory myopathies. (Internal Medicine 36: 876-881, 1997)
doi:10.2169/internalmedicine.36.876 fatcat:bbr2axts4ffd5npcxta73glige