Building biological foundries for next-generation synthetic biology

Ran Chao, YongBo Yuan, HuiMin Zhao
2015 Science China Life Sciences  
Synthetic biology is an interdisciplinary field that takes top-down approaches to understand and engineer biological systems through design-build-test cycles. A number of advances in this relatively young field have greatly accelerated such engineering cycles. Specifically, various innovative tools were developed for in silico biosystems design, DNA de novo synthesis and assembly, construct verification, as well as metabolite analysis, which have laid a solid foundation for building biological
more » ... oundries for rapid prototyping of improved or novel biosystems. This review summarizes the state-of-the-art technologies for synthetic biology and discusses the challenges to establish such biological foundries. biofabrication, automation, metabolic engineering, biosystems design, DNA assembly, DNA sequencing, metabolite analysis Citation: Chao R, Yuan YB, Zhao HM. Building biological foundries for next-generation synthetic biology. Sci China Life Sci, 2015, 58: 658 -665,
doi:10.1007/s11427-015-4866-8 pmid:25985756 fatcat:l7irzybvhzaslewlvnicjkp2oi