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The impact of education inequality on rheumatoid arthritis risk is mediated by smoking and body mass index: mendelian randomization study
[article]
2021
medRxiv
pre-print
AbstractObjectiveTo estimate the causal relationship between educational attainment – as a proxy for socioeconomic inequality – and risk of RA and quantify the roles of cigarette smoking and body mass index (BMI) as potential mediators.MethodsUsing the largest genome-wide association studies (GWAS), we performed a two-sample Mendelian randomization (MR) study of genetically predicted educational attainment (instrumented using 1265 variants from 766,345 individuals) and RA (14,361 cases, 43,923
doi:10.1101/2021.04.20.21254536
fatcat:awcnyacgtvbqbkrf6bi4gmi7mu