LC–MS Based Detection of Differential Protein Expression

Leepika Tuli, Habtom W. Ressom
2009 Journal of Proteomics & Bioinformatics  
While several techniques are available in proteomics, LC-MS based analysis of complex protein/peptide mixtures has turned out to be a mainstream analytical technique for quantitative proteomics. Significant technical advances at both sample preparation/separation and mass spectrometry levels have revolutionized comprehensive proteome analysis. Moreover, automation and robotics for sample handling process permit multiple sampling with high throughput.
doi:10.4172/jpb.1000102 pmid:20473349 pmcid:PMC2867618 fatcat:weyv7yegwjhlnotanbmsm7fjca