Spontaneous adverse drug reaction (ADR) reporting is the corner stone of pharmacovigilance. ADR reporting with yellow post has tremendously improved safety of drugs. The aim of this study was to assess the knowledge, attitude and practice (KAP) of health professionals towards ADR reporting in Jimma zone hospitals, South Western Ethiopia and to suggest possible ways of improving reporting. A cross sectional study was conducted using a structured self-administered questionnaire and the data was

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... mpiled and analyzed using SPSS version 16.0 stastical soft ware. All health professionals found in the data collection period were included in the study. A total of 203 health professionals (143 males and 60 females) were interviewed. Among this only,76(37.4%) were awared about the presence of national ADR reporting centre in Ethiopia and only 42 (20.6 %) were aware of the yellow prepaid post in Ethiopia. 82 (40.4%) of the respondents were encouraged to report ADR if the reaction is to a new product. Education and training on how to report ADR to health professionals was the most emphasised means of improving ADR reporting. Only 8.8% of the respondents had ever reported using the yellow Most of the respondents believe on the importance of ADR reporting but there is a knowledge gap on how to report. Most of the respondent's did not report ADR in their life time. The majority of the respondents emphasized on education and training to fill this gap.