Chronic invasive granulomatous fungal sinusitis (CIGFS) caused by cryptococcus is extremely rare, especially in immunocompetent patients. We report two cases of CIGFS caused by cryptococcus in immunocompetent patients. Case 1 was infected in the left ethmoid sinus with orbital invaded later. Case 2 was infected in the left max-illary sinus and sphenoid sinus with Intracranial invaded later. The two cases all underwent two surgical operations, and postoperative pathology showed granulomatous

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... ammation. The third postoperative pathology confirmed cryptococcal infection by PAS and AB-PAS stain. Case 1 was underwent orbital exenteration debridement and appropriate antifungal therapy after surgery, and was followed up for 18 months without recurrence. Case 2 had no chance of surgery at last and went to a higher level hospital for continue therapy and then losted follow-up. Early recognition of cryptococcal sinusitis and appropriate surgery with administration of appropriate antifungal therapy has a great impact on the good prognosis.