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Overexpression of the Serotonin 5-HT2B Receptor in Heart Leads to Abnormal Mitochondrial Function and Cardiac Hypertrophy
Background-Identification of factors regulating myocardial structure and function is important to understand the pathogenesis of heart disease. We previously reported that 5-HT 2B receptor ablation in mice leads to dilated cardiomyopathy. In this study, we investigated the pathological consequence of overexpressing 5-HT 2B receptors in heart in vivo. Methods and Results-We have generated transgenic mice overexpressing the Gq-coupled 5-HT 2B receptor specifically in heart. We found thatdoi:10.1161/01.cir.0000074224.57016.01 pmid:12810613 fatcat:dhyraenferf5pe7sr7t224ck4u