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The unfolded protein response of the endoplasmic reticulum supports mitochondrial biogenesis by buffering non-imported proteins
Almost all mitochondrial proteins are synthesized in the cytosol and subsequently targeted to mitochondria. The accumulation of non-imported precursor proteins occurring upon mitochondrial dysfunction can challenge cellular protein homeostasis. Here we show that blocking protein translocation into mitochondria results in the accumulation of mitochondrial membrane proteins at the endoplasmic reticulum, thereby triggering the unfolded protein response (UPR-ER). Moreover, we find thatdoi:10.1101/2021.05.19.444788 fatcat:iuxuywfw4vhszpvu6r5m35yocm