Over-expression of RNA polymerase II subunit L in human endometrial cancer [post]

Shahan Mamoor
2021 unpublished
Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified RNA polymerase II subunit L, encoded by POLR2L, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. POLR2L was expressed at significantly higher levels in
more » ... al tumor tissues as compared to the endometrium. Importantly, primary tumor expression of POLR2L was correlated with recurrence-free survival in patients with endometrial cancer. POLR2L may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.
doi:10.31219/osf.io/5nmr7 fatcat:v5iwdpklxrfmfo26vmmf6hfmz4