Co-existence of network architectures supporting the human gut microbiome

C.V. Hall, A. Lord, R. Betzel, M. Zakrewski, L.A. Simms, A. Zalesky, G. Radford-Smith, L. Cocchi
2019 iScience  
Microbial organisms of the human gut microbiome do not exist in isolation but form complex and diverse interactions to maintain health and reduce risk of disease development. The organization of the gut microbiome is assumed to be a singular assortative network, where interactions between operational taxonomic units (OTUs) can readily be clustered into segregated and distinct communities. Here, we leverage recent methodological advances in network modeling to assess whether communities in the
more » ... man microbiome exhibit a single network structure or whether co-existing mesoscale network architectures are present. We found evidence for core-periphery structures in the microbiome, supported by strong, assortative community interactions. This complex architecture, coupled with previously reported functional roles of OTUs, provides a nuanced understanding of how the microbiome simultaneously promotes high microbial diversity and maintains functional redundancy.
doi:10.1016/j.isci.2019.11.032 pmid:31812808 pmcid:PMC6911941 fatcat:yiacp4lsr5hxllgcwglv3r6l7i