Effect of hemodialysis session on acute changes in inflammatory and cardiovascular risk biomarkers

Lavín Gómez Bernardo-Alio, García Unzueta María-Teresa, Guerra Ruiz Armando-Raúl, San-Martín Sonia Pérez, Berja Ana, Rodríguez Natalia Fañanás, Espejo Sara Díez, González-Lamuño Leguina Domingo
2020 Journal of Cardiology and Cardiovascular Medicine  
How to cite this article: Gómez BAL, Unzueta MTG, Ruiz ARG, San-Martín SP, Berja A, et al. Effect of hemodialysis session on acute changes in infl ammatory and cardiovascular risk biomarkers. J Cardiol Cardiovasc Med. 2020; 5: 004-0010. Abstract Background: Infl ammation is associated with enhanced cardiovascular risk profi le and increased cardiovascular mortality in end-stage kidney disease patients undergoing hemodialysis. Mechanisms of activated acute phase reaction in patients on chronic
more » ... tients on chronic hemodialysis remain to be identifi ed. As successful treatment of the infl ammatory condition in these patients may improve long-term survival, we studied potential changes in different infl ammatory biomarkers of cardiovascular risk in end-stage kidney disease patients after a mid-week hemodialysis session. Methods: Infl ammatory biomarkers of cardiovascular risk (cystatin-C, homocysteine, C-reactive protein, procalcitonin, pentraxin-3, serum amyloid-A) and atherogenic plasma lipoproteins (Lipoprotein(a), cholesterol low and high density lipoproteins) were studied in 21 end-stage kidney disease patients previously and after a mid-week hemodialysis session. Results: We found a signifi cant reduction in serum levels of low molecular weight molecules: cystatin-C (5.56 to 1.85 mg/L, 66.73%, p < 0.001), homocysteine (22.85 to 13.25 μmol/L, 42.01%, p < 0.001) and procalcitonin (0.788 to 0.457 ng/mL, 42.01%, p < 0.001). Large molecules as C-reactive protein (9.70 to 9.90 mg/L, 2.06%, p = 0.022) and pentraxin-3 (1.67 to 4.28 ng/mL, 156%, p < 0.001) increased, but serum amyloid-A decreased (15.90 to 12.70 mg/L, 20.13%, p < 0.05). There was no change in Lipoprotein (a) levels. Conclusion: Pentraxin-3 was a more specifi c infl ammatory vascular marker than C-reactive protein, and the best infl ammatory marker associated with hemodialysis. Homocysteine, procalcitonin and the other small proteins could be released and removed during hemodialysis session. Further studies are needed to understand the behavior and signifi cance of these markers after successive hemodialysis. Effect of hemodialysis session on acute changes in infl ammatory and cardiovascular risk biomarkers https://www.heighpubs.org/jccm 005 https://doi.org/10.29328/journal.jccm.1001077 Effect of hemodialysis session on acute changes in infl ammatory and cardiovascular risk biomarkers https://www.heighpubs.org/jccm 006 https://doi.
doi:10.29328/journal.jccm.1001077 fatcat:uuywd6cesbeb3fqlxvhje6txjq