Anti-Diarrheal Evaluation of the Aqueous Ethanol Extract of Jateorhiza macrantha (Hook F.) Exell Mendonça (Menispermaceae) Leaves
Saudi Journal of Biomedical Research
Jateorhiza macrantha is a medicinal plant used in ethnomedicine for dysentery, cough, boil, ulcer, and inflammation, wound healing and venomous bite. This study is aimed at evaluating the anti-diarrheal activity of the aqueous ethanol extract from the leaves of Jateorhiza macrantha. The aqueous ethanol extract (AEE) was obtained by exhaustive cold maceration in 70% aqueous. The anti-diarrheal and anti-motility activities of the AEE were evaluated using the castor oil induced diarrheal and
... diarrheal and charcoal meal animal assays respectively. Loperamide (2mg/kg bw) and atropine sulphate (5 mg/kg bw) were used as reference anti-diarrheal and anti-motility agents respectively for comparison. The AEE shows dose dependent anti-diarrheal and anti-motility activities. The trend in the anti-diarrheal activity (% inhibition of fecal mass compared to negative control group): loperamide-2mg/kgbw (67.42%) > AEJML-400mg/kgbw (64.49%)>AEJML-200mg/kgbw (41.57%)>AEJML-100mg/kgbw (13.48%) and anti-motility (% inhibition of intestinal peristalsis index compared to negative control group): AEJML-250mg/kgbw(71.70%)>AEJML-125mg/kgbw(30.10%)>AEJML-100mg/kgbw(0.37%). The trend in anti-castor oil induced diarrheal and anti-motility activities obtained in this study for Jateorhiza macrantha justifies its use in ethno medicine for the treatment of diarrheal and related gas intestinal tracts illness.