Mathematical and Computational Modeling in Complex Biological Systems

Zhiwei Ji, Ke Yan, Wenyang Li, Haigen Hu, Xiaoliang Zhu
2017 BioMed Research International  
The biological process and molecular functions involved in the cancer progression remain difficult to understand for biologists and clinical doctors. Recent developments in high-throughput technologies urge the systems biology to achieve more precise models for complex diseases. Computational and mathematical models are gradually being used to help us understand the omics data produced by high-throughput experimental techniques. The use of computational models in systems biology allows us to
more » ... lore the pathogenesis of complex diseases, improve our understanding of the latent molecular mechanisms, and promote treatment strategy optimization and new drug discovery. Currently, it is urgent to bridge the gap between the developments of high-throughput technologies and systemic modeling of the biological process in cancer research. In this review, we firstly studied several typical mathematical modeling approaches of biological systems in different scales and deeply analyzed their characteristics, advantages, applications, and limitations. Next, three potential research directions in systems modeling were summarized. To conclude, this review provides an update of important solutions using computational modeling approaches in systems biology.
doi:10.1155/2017/5958321 pmid:28386558 pmcid:PMC5366773 fatcat:e6pyjhqdyzfllk6q2l5yjzssf4