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Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models
Journal of Neuroscience
The protein NOS1AP/CAPON mediates signaling from a protein complex of NMDA receptor, PSD95 and nNOS. The only stroke trial for neuroprotectants that showed benefit to patients targeted this ternary complex. NOS1AP/nNOS interaction regulates small GTPases, iron transport, p38MAPK-linked excitotoxicity, and anxiety. Moreover, the nos1ap gene is linked to disorders from schizophrenia, posttraumatic stress disorder, and autism to cardiovascular disorders and breast cancer. Understanding proteindoi:10.1523/jneurosci.0037-15.2015 pmid:25972165 fatcat:jyflrqyezregjir2dieqmcoyna