Разработка системы адресной доставки противоопухолевых препаратов на основе мезенхимальных стволовых клеток человека, модифицированных гибридными полимерными капсулами

Алексей Пельтек, Санкт-Петербургский политехнический университет Петра Великого. Институт биомедицинских систем и биотехнологий, Валерий Октябрьский, Александр Тимин
2019
In the given work, an optimal method for multipotent mesenchymal stromal cells modification using hybrid polyelectrolyte capsules containing the cytostatic drug vincristine was developed. The effect of these capsules on cell viability, as well as their effect on spontaneous and directed migration, was estimated. The migration of MMSC towards spheroids from primary tumor cells was investigated. A comparative analysis of the antitumor activi-ty of MSC modified with vincristine capsules in
more » ... capsules in comparison with the free drug was performed.
doi:10.18720/spbpu/3/2019/vr/vr19-824 fatcat:tmonfyfkbvec5gtw4t2ubyvbg4