Differential Ethanol Sensitivity of Subpopulations of GABAA Synapses Onto Rat Hippocampal CA1 Pyramidal Neurons

J. L. Weiner, C. Gu, T. V. Dunwiddie
1997 Journal of Neurophysiology  
Weiner, J. L., C. Gu, and T. V. Dunwiddie. Differential ethanol iological (Aguayo 1990; Celantano et al. 1988 ; Reynolds sensitivity of subpopulations of GABA A synapses onto rat hippoand Prasad 1991) studies have demonstrated that intoxicatcampal CA1 pyramidal neurons. J. Neurophysiol. 77: 1306-1312, ing concentrations of ethanol (10-100 mM) can potentiate 1997. The actions of ethanol on g-aminobutyric acid-A (GABA A ) GABA A receptor function. However, in a number of studies receptor-mediated
more » ... s receptor-mediated synaptic transmission in rat hippocampal CA1 in which similar methods were used, this interaction was not neurons remain controversial. Recent studies have reported that observed (Mihic et al. 1992; Morelli et al. 1988 ; Osmanovic intoxicating concentrations of ethanol (10-100 mM) can potentiand Shefner 1990). In fact, it has proven difficult to identify ate, inhibit, or have no effect on GABA A receptor-mediated synap-
doi:10.1152/jn.1997.77.3.1306 pmid:9084598 fatcat:xvxtljynxrcldls2gryuixgn3m