Analysis of the Runx3 expression during experiemental autoimmune encephalomyelitis

Beatriz Souza Lopes, Alessandro dos Santos Farias, Ana Maria Marques
2018 Revista dos Trabalhos de Iniciação Científica da UNICAMP  
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS), which is attributed to a self-sustaining autoimmune mechanism. The majority of the knowledge regarding MS autoagressive mechanisms is resultant of studies performed in its experimental model (mice) the experimental autoimmune encephalomyelitis (EAE).Although, the literature reports that the EAE is mediated by proinflammatory CD4+ T cells , isn't completely clear how these cells (known as helper
more » ... would be able of initiate the disease when adoptively transferred to healthy animals.We believe that the Runx3 gene presents a central role in the progression and regulation of the effector activity in CD4+ encephalitogenic lymphocytes.
doi:10.20396/revpibic262018204 fatcat:zkn26et2fvbo3flbwmx7h3n6v4