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Investigating asthma heterogeneity through shared and distinct genetics: insights from genome-wide cross-trait analysis
2020
Journal of Allergy and Clinical Immunology
Asthma is a heterogeneous respiratory disease reflecting distinct pathobiological mechanisms. These mechanisms are based, at least partly, on different genetic factors shared by many other conditions, such as allergic diseases and obesity. Investigating the shared genetic effects enables better understanding the mechanisms of phenotypic correlations and is less subject to confounding by environmental factors. The increasing availability of large-scale genome-wide association study (GWAS) for
doi:10.1016/j.jaci.2020.07.004
pmid:32693092
pmcid:PMC7368660
fatcat:jmiujfjxubhbdhcnfz5zanqz6u