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Precision genetic modification techniques Using precision genetic modification (Pgm) techniques, researchers can target specific sequences in complex genomes and precisely introduce modifications including single nucleotide changes. Implementation of these techniques required several breakthroughs, including the ability to engineer recognition of a specific DnA sequence and generate a specific double-stranded DnA break (DsB). homology-directed repair (hDr) of this site-specific DsB can thendoi:10.1007/s00425-014-2029-y pmid:24510124 fatcat:ofwexpfyfzdsta7qhpxxamn6hq