An Integrated Approach to the Meta-Analysis of Genetic Association Studies using Mendelian Randomization

C. Minelli
2004 American Journal of Epidemiology  
Joint senior authors. by guest on September 6, 2015 http://aje.oxfordjournals.org/ Downloaded from 446 Minelli et al. Am J Epidemiol 2004;160:445-452 by guest on September 6, 2015 http://aje.oxfordjournals.org/ Downloaded from by guest on September 6, 2015 http://aje.oxfordjournals.org/ Downloaded from 448 Minelli et al. Am J Epidemiol 2004;160:445-452 A recent genetic meta-analysis of individual patient data has shown an increased risk of coronary heart disease of approximately 16 percent
more » ... ely 16 percent associated with genotype TT as compared with CC (odds ratio = 1.16, 95 percent CI: 1.05, 1.28) (13). This result was similar to that of another metaanalysis published at the same time but carried out on aggregated data, which showed a pooled odds ratio of 1.21 for the TT genotype (95 percent CI: 1.06, 1.39) (14). The latter FIGURE 2. Two-column forest plot and pooled estimates for genotype-disease and genotype-phenotype associations. A, Asians; E, Europeans; F, females; M, males. Horizontal bars, 95% confidence interval. (For references, see the technical report by Minelli et al. (5).) by guest on September 6, 2015 http://aje.oxfordjournals.org/ Downloaded from
doi:10.1093/aje/kwh228 pmid:15321841 fatcat:4twpzg2zvned7i5rpeavu6ghxi