Focal Brain Lesions and Language Development

J Gordon Millichap
2005 Pediatric Neurology Briefs  
dup7ql 1.23, located in the long q arm of chromosome 7, at the region commonly deleted in WBS. The characteristic facial phenotype is also shared with a previously described syndrome of delay in expressive language and supernumerary ring chromosome 7. This consists of a high, broad nose, posteriorly rotated ears, high-arched palate, and short philtrum. These facies coupled with expressive language delay should prompt genetic testing for duplication of the WBS region. An editorial perspective
more » ... genes, speech, and language" (Fisher SE. N Engl J Med Oct 20, 2005;353:1655-1657) refers to a specific gene, FOXP2, located in chromosome 7q31, implicated previously in verbal dyspraxia and orofacial dyspraxia (Macdermot KD et al. Am J Hum Genet 2005;76:1074-1080; cited by Somerville et al). The above study that identifies a second locus on chromosome 7 associated with language delay and oromotor dyspraxia emphasizes the potential of using molecular diagnostics for early identification of children at increased risk of language and speech impairment.
doi:10.15844/pedneurbriefs-19-11-2 fatcat:k7t7gaipvfetfgnik7sgcme3ny