Multiple Myeloma Complicated by Autoimmune Hemolytic Anemia

Hideho WADA, Kenichiro YATA, Makoto MIKAMI, Shinichiro SUEMORI, Hidekazu NAKANISHI, Toshinori KONDO, Takayuki TSUJIOKA, Yoshimasa SUETSUGU, Takemi OTSUKI, Yoshito SADAHIRA, Yoshihito YAWATA, Takashi SUGIHARA
2004 Internal medicine (Tokyo. 1992)  
A 57-year-old man was admitted with severe anemia and hypergamma globulinemia. After a diagnosis of multiple myeloma and autoimmune hemolytic anemia was made, chemotherapy rapidly decreased the M-protein level and improved his anemia with normalization of the direct Coombs test. The immunoglobulin binding to the patient's red cells was immunoglobulin G kappa chain like the myeloma M-protein. However, monoclonal immunoglobulin G derived from short-term culture of the patient's bone marrow
more » ... lear cells did not bind to a panel of red cells. Therefore, the relationship between the M protein produced by his myeloma cells and hemolysis remained unclear. (Internal Medicine 43: [595][596][597][598] 2004)
doi:10.2169/internalmedicine.43.595 pmid:15335188 fatcat:kfex2whtrrbqdfwodazwixqs2i