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NAD+ repletion with niacin counteracts cancer cachexia
[article]
2022
bioRxiv
pre-print
Cachexia is a debilitating wasting syndrome and highly prevalent comorbidity in cancer patients. It manifests especially with energy and mitochondrial metabolism aberrations that promote tissue wasting. We recently identified nicotinamide adenine dinucleotide (NAD+) loss to associate with muscle mitochondrial dysfunction in cancer hosts. In this study we confirmed that depletion of NAD+ and downregulation of Nrk2, an NAD+ biosynthetic enzyme, are common features of different mouse models and
doi:10.1101/2022.07.06.499010
fatcat:mns7zldhe5fajegxqpolsrjiqe