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Understanding the Genome-Wide Response of Streptomyces coelicolor to the Glycopeptide Antibiotic Teicoplanin
The glycopeptide antibiotics vancomycin and teicoplanin are clinically important as a secondline therapy to treat nosocomial infections caused by Gram-positive pathogens. Glycopeptide antibiotics universally target the terminal residues, D-Alanyl-D-Alanine on the cell wall peptidoglycan intermediate lipid II, interfering with peptidoglycan biosynthesis and weakening the cell wall. A general resistance mechanism to these antibiotics requires a core set of genes, vanRSHAX, that detect adoi:10.24384/14qa-m159 fatcat:bg52stisnzfdfoi4hrc6oq7d6q