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APOE-4 Genotype and Neurophysiological Vulnerability to Alzheimer's and Cognitive Aging
2009
Annual Review of Clinical Psychology
Many years before receiving a clinical diagnosis of Alzheimer's disease (AD), patients experience evidence of cognitive decline. Recent studies using a variety of brain imaging technologies have detected subtle changes in brain structure and function in normal adults with a genetic risk for AD; these brain changes have similar pathological features as AD, and some appear to be predictive of future cognitive decline. This review examines the most recent data on brain changes in genetic risk for
doi:10.1146/annurev.clinpsy.032408.153625
pmid:19327032
pmcid:PMC3118550
fatcat:y6rar2w4cne45pzhnndx3nl2dy