Mimivirus and the emerging concept of "giant" virus

Jean-Michel Claverie, Hiroyuki Ogata, Stéphane Audic, Chantal Abergel, Karsten Suhre, Pierre-Edouard Fournier
2006 Virus Research  
The recently discovered Acanthamoeba polyphaga Mimivirus is the largest known DNA virus. Its particle size (750 nm), genome length (1.2 million bp) and large gene repertoire (911 protein coding genes) blur the established boundaries between viruses and parasitic cellular organisms. In addition, the analysis of its genome sequence identified many types of genes never before encountered in a virus, including aminoacyl-tRNA synthetases and other central components of the translation machinery
more » ... ously thought to be the signature of cellular organisms. In this article, we examine how the finding of such a giant virus might durably influence the way we look at microbial biodiversity, and lead us to revise the classification of microbial domains and life forms. We propose to introduce the word "girus" to recognize the intermediate status of these giant DNA viruses, the genome complexity of which makes them closer to small parasitic prokaryotes than to regular viruses.
doi:10.1016/j.virusres.2006.01.008 pmid:16469402 fatcat:fuyipzukebennax6f7ehrmoi6q