MOLECULAR NEUROBIOLOGY OF PAIN. 1st Edition. 1997. Volume 9, IASP Series - "Progress of Pain Research and Management" Edited by David Borsook. Published by IASP Press. 369 pages.$C98.80

Neil A. Hagen
1998 Canadian Journal of Neurological Sciences  
The book is well organized, and nicely assembled with liberal use of clear diagrams, vector maps, tables, and where appropriate, novel data. There are three sections to the book: Part One deals with vectors and promoter systems; Part Two with neuro-oncology; and Part Three with disorders that affect the central nervous system (CNS) such as Parkinson's disease, stroke, and CNS storage diseases. The text begins with a description of retroviral vectors and their utility, including the use of
more » ... ng the use of regulatible promoters. The ability to regulate transgene expression with tissue or cell specificity by means of retroviruses is highly desirable, and the methodology of such systems is clearly described and well illustrated. As there are a number of clinical trials in progress today which utilize retroviral vectors for patients with brain tumors, this particular chapter gives exceptional background information for the interested reader. Subsequent chapters in Part One describe the advantages of using other vector systems such as adenoviral, HIV recombinate, adenoassociated viral, Epstein-Barr viral, and lentiviral vector. Each of these chapters is well balanced describing the potentials and pitfalls associated with each virus.
doi:10.1017/s031716710003448x fatcat:zdkw7qbmkveqhgl4vistioqgb4