2 The abbreviations used are: ENaC, epithelial amiloride-sensitive sodium channel; ⌬I ami , amiloride-sensitive current; NDRG2, N-Myc downstreamregulated gene 2; Sgk1, serum-and glucocorticoid-inducible kinase; FRT, Fisher rat thyroid; I SC-ami , amiloride-sensitive short-circuit current; Nedd4-2, neuronal precursor cell-expressed developmentally down-regulated 4-2; RCCD, rat kidney cortical collecting duct cell line; wt, wild-type; MBS, modified Barth's solution; R te , transepithelial

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... ce; V te , transepithelial voltage; PBS, phosphate-buffered saline; I/V, current-voltage; N4WBP5A, Nedd4 WW-domain binding protein 5A; MESK2, misexpression suppressor of dominant-negative KSR (kinase suppressor of Ras).