Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample

Minna T. Jänis, Sarah Siggins, Esa Tahvanainen, Riikka Vikstedt, Kaisa Silander, Jari Metso, Arpo Aromaa, Marja-Riitta Taskinen, Vesa M. Olkkonen, Matti Jauhiainen, Christian Ehnholm
2004 Journal of Lipid Research  
Human serum phospholipid transfer protein (PLTP) exists as a catalytically active (HA-PLTP) and a lowactive (LA-PLTP) form. In this study, the association of PLTP activity and the concentrations of both forms with lipid and carbohydrate parameters were investigated. In a random Finnish population sample, serum PLTP concentration (n ‫؍‬ 250) was 6.56 ؎ 1.45 mg/l, the mean lipoproteinindependent (PLTP exo ) phospholipid transfer activity was 6.59 ؎ 1.66 mol/ml/h, and the mean
more » ... ipoprotein-dependent (PLTP endo ) activity was 1.37 ؎ 0.29 mol/ml/h. Of the serum PLTP concentration, ‫ف‬ 46% was in a catalytically active form. HA-PLTP concentration correlated positively with serum PLTP exo activity ( r ‫؍‬ 0.380, P Ͻ 0.001), HDL cholesterol ( r ‫؍‬ 0.291, P Ͻ 0.001), and apolipoprotein A-I ( r ‫؍‬ 0.187, P Ͻ 0.01). Of the potential regulatory factors for PLTP, apolipoprotein E showed a weak positive correlation with serum PLTP exo ( r ‫؍‬ 0.154, P Ͻ 0.05) and PLTP endo ( r ‫؍‬ 0.192, P Ͻ 0.01) activity but not with PLTP concentration. Weak associations were also observed between PLTP parameters and determinants of glucose homeostasis (glucose, insulin, and homeostasis model assessment for insulin resistance). The present data on PLTP activity and concentration reveal novel connections of the two PLTP forms to lipid and carbohydrate metabolism. -Jänis, M. T., S. Siggins, E. Tahvanainen, R. Vikstedt, K. Silander, J. Metso, A. Aromaa, M-R. Taskinen, V. M. Olkkonen, M. Jauhiainen, and C. Ehnholm. Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample.
doi:10.1194/jlr.m400250-jlr200 pmid:15342679 fatcat:qrenzt7655hc7emaqq2aj3miaq