AKTIVITAS ANTIDIABETES SENYAWA ANALOG KALKON DAN TURUNAN KALKON (SUBTITUEN NAFTALEN) TERHADAP ENZIM α-GLUKOSIDASE ANTIDIABETIC ACTIVITY OF CHALCONE ANALOGUES AND CHALCONE DERIVATIVE (NAPHTALENE SUBSTITUEN) DUE TO α-GLUKOSIDASE

Semirata Bidang Mipa Bks-Ptn Barat Universitas Prosiding, Pontianak Tanjungpura, Hal
2015 unpublished
This research done to know activity antidiabetic of the chalcone analogues and chalcone derivative applies method inhibition of α-glukosidase in vitro. Chalcone is one of the secondary metabolite class of flavonoids that have various biological activities such as antimicrobial, anti-cancer, cytotoxicity, anticholera, anti-inflammatory and antitumor. Chalcone used as the intermediates substances for synthesis many compounds such as flavonon, flavonoids , flavones , flavonols , and important
more » ... and important precursor for synthesis of heterocyclic coumpounds such as benzothiazepine. Chalcone (E)-1,3-di(naphthalene-1-yl)prop-2-en-1-on (K), Chalcone (E)-3-(naftalen-1-yl)-1-(naphthalene-2-yl)prop-2-en-1-on (L) and benzotiazepin (E)-2,4-di-(naphthalene-1-yl)benzo-(1,4)tiazepin (M) that have been synthesized in previous research. Antidiabetic test of Chalcone analogues (K & L) and chalcone derivative (M) shown by % inhibition value of α-glukosidase. % inhibition value at concentration of 100 ppm of each chalcone is 17.71% (chalcone K), 2.91% (chalcone L) and 7.89% (benzothiazepine M). Resistance activity (IC 50) of each chalcone analogues and chalcone derivative is more than 1000 ppm. It's mean chalcone analogues and chalcone derivative have low potential activity antidiabetic. Chalcone K, chalcone L and benzothiazepin M synthesized haven't substituent groups which can encourage the movement of electrons and the steric effect present of chalcone K (MR 308.1262 m / z), chalcone L (MR 308, 1288 m / z) and benzothiazepine M (MR 415, 485 m / z). Due to steric effect synthesized compounds can not enter into the enzyme active site. ABSTRAK Penelitian ini dilakukan untuk mengetahui aktivitas antidiabetes senyawa analog kalkon dan turunan kalkon menggunakan metode inhibisi terhadap enzim α-glukosidase secara in vitro. Kalkon merupakan salah satu metabolit sekunder golongan flavonoid yang mempunyai berbagai macam aktivitas, diantaranya adalah sebagai antimikroba, anti kanker, sitotoksitas, anti kolera, anti inflamasi dan anti tumor. Kalkon merupakan senyawa intermediet untuk mensintesis senyawa flavonoid lain seperti flavonon, flavon, flavonol dan juga merupakan prekursor dalam sintesis heterosiklik penting lainnya seperti benzotiazepin. Pada penelitian ini dilakukan uji aktivitas antidiabetes terhadap senyawa kalkon (E)-1,3-di(naftalen-1-il)prop-2-en-1-on (K), senyawa kalkon (E)-3-(naftalen-1-il)-1-(naftalen-2-il)prop-2-en-1-on (L) dan senyawa benzotiazepin benzotiazepin (E)-2,4-di(naftalen-1-il)benzo-(1,4)tiazepin (M) yang telah disintesis pada penelitian sebelumnya. Hasil penelitian menunjukkan % inhibisi terhadap enzim α-glukosidase pada konsentrasi
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