Meningitis Carcinomatosa Originating from an Alpha Fetoprotein-producing Gastric Cancer

Tomoyuki TSUJIKAWA, Hirotaka TSUKAMOTO, Akihiko ITOH, Akira ANDOH, Masaya SASAKI, Shigeki KOYAMA, Yoshihide FUJIYAMA, Tadao BAMBA
2000 Internal medicine (Tokyo. 1992)  
Alpha fetoprotein (AFP)-producing gastric cancer is relatively rare and meningitis carcinomatosa is similarly a rare manifestation amongthe neoplastic diseases. There have been no previous reports of meningitis carcinomatosa originating from AFP-producing gastric cancer. A 68-year-old manwith AFP-producinggastric cancer was treated with cisplatin and doxifluridine because of multiple liver metastases. Although the liver lesion was reduced to 30% of pretreatment size after 6 courses of
more » ... py, meningitis carcinomatosa subsequently occurred. Immunostaining ofAFP and magnetic resonance imaging (MRI) were useful in the diagnosis of meningitis caused by AFP producing cancer cells.
doi:10.2169/internalmedicine.39.223 fatcat:46swb7udlbb77p33zud2kggdky