The oral route is the safest and marketable route for the administration of therapeutic agents for the use of human as well as the veterinary. Pharmaceutical scientists throughout the world are inspecting Orodispersible films (ODFs) as an innovative drug delivery tool. Orodispersible films are now a days are recognized as an alternative approach to conventional dosage form. These thin oral films containing API have ability to releases the drug quickly for both systemic and local action via oral

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... or, sublingual routes. The design of an effective orodispersible film requires an encyclopedic knowledge of pharmaceutical properties of drugs and polymers along with best fit selection of manufacturing process. Hence the motive of this review is to provide an overview of the condemnatory factors that affect the formulation of orodispersible films which includes the physicochemical properties of polymers and drugs, as well as the characterization methods to outwit the difficulties associated with formulation design. It also underlines the latest approaches and trends of the pharmaceutical companies in developing thin film products.