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Anti-atherosclerotic Activity of Platycodin D Derived from Roots of Platycodon grandiflorum in Human Endothelial Cells
Biological and Pharmaceutical Bulletin
This study examined the effects of platycodin D (PD), a triterpene saponin from the the root of Platycodon grandiflorum A.DC on human umbilical vein endothelial cells (HUVECs) in vitro, which were pretreated with PD (0.01, 0.15, 0.25 mg/mL), respectively, and treated with 50 mg/L oxidized low-density lipoprotein (oxLDL). The levels of nitric oxide (NO) and malonaldehyde (MAD) in the culture medium, vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1)doi:10.1248/bpb.b-y110129 pmid:22863916 fatcat:muj54csumffhfeykocrgvwt3jm