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Background-Exercise stress testing alone or with perfusion imaging is the standard screening method to determine the presence of obstructive coronary artery disease (CAD) in people with chest pain. In asymptomatic individuals with a family history of premature CAD, it is unclear whether abnormalities on these functional exercise tests represent significant coronary disease. Methods and Results-An abnormal exercise test, thallium scan, or both occurred in 153 (21%) of 734 asymptomatic siblingsdoi:10.1161/01.cir.0000048127.93169.88 pmid:12578872 fatcat:q6t56akt4jfbbg27psqc3b65vy