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A Study on Mutation of the Exon 10 of the LDLR gene in Hypercholesterolemia Patients in Ardebil, Iran
Objective: Familial hypercholesterolemia (FH) is an autosomal dominant disease mainly attributed to mutations in the low-density lipoprotein receptor gene (LDLR). This study aims to investigate molecular changes in the LDLR gene in patients with high cholesterol in individuals from Ardebil Province, Iran. Methods: We evaluated 100 patients with suspected FH from Ardebil Province. DNA samples using primers LDLR gene and exon 10 PCR-SSCP method was tested and modified bands on gel electrophoresisfatcat:dne24v5pdbgyxcghe3omk7bfym