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An Integrated Bidirectional Multi-Channel Opto-Electro Arbitrary Waveform Stimulator For Treating Motor Neurone Disease

Dai Jiang, Yu Wu, Noora Almarri, Maryam Habibollahi, Fangqi Liu, J. Barney Bryson, Linda Greensmith, Andreas Demosthenous
2021 2021 IEEE International Symposium on Circuits and Systems (ISCAS)  

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This paper presents a prototype integrated bidirectional stimulator ASIC capable of mixed opto-electro stimulation and electrophysiological signal recording. The development is part of the research into a fully implantable device for treating motor neurone disease using optogenetics and stem cell technology. The ASIC consists of 4 stimulator units, each featuring 16-channel optical and electrical stimulation using arbitrary current waveforms with an amplitude up to 16 mA and a frequency from
more » ... Hz to 50 kHz, and a recording front-end with a programmable bandwidth of 1 Hz to 4 kHz, and a programmable amplifier gain up to 74 dB. The ASIC was implemented in a 0.18-µm CMOS technology. Simulated performance in stimulation and recording is presented.
doi:10.1109/iscas51556.2021.9401220 fatcat:tiph5s67wrhevmfbnf2jja3iru
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Dai Jiang, Yu Wu, Noora Almarri, Maryam Habibollahi, Fangqi Liu, J. Barney Bryson, Linda Greensmith, Andreas Demosthenous. "An Integrated Bidirectional Multi-Channel Opto-Electro Arbitrary Waveform Stimulator For Treating Motor Neurone Disease." 2021 IEEE International Symposium on Circuits and Systems (ISCAS) (2021)