In mammogram, masses are primary indication of breast cancer; and it is necessary to classify them as malignant or benign. In this classification task, Computer Aided Diagnostic (CAD) system by using ensemble learning is able to assist radiologists to have better diagnosis of mammogram images. Ensemble learning consists of two steps, generating multiple base classifiers and then combining them together. However, combining all base classifier in the ensemble model increases the computational

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... and time. Therefore, ensemble pruning is an important step in ensemble learning to select the ensemble's members. Due to huge subsets of combination in the ensemble, selecting the proper ensemble subset is desirable. The objective of this paper is to select the optimal ensemble subset by using Bee Algorithm (BA). A pool of different classifier models such as Support vector machine, k-nearest neighbour and linear discriminant analysis classifiers have been trained using different samples of training data and 12 groups of features. Then, by using this pool of classifier models, BA was used to exploit and explore random uniform combination subsets of the trained classifiers. As a result, the best subset will be selected as the optimal ensemble. The mammogram image dataset that was used to test the model has been collected from Hospital Kuala Lumpur (HKL) and consists of 263 benign and malignant masses. The proposed method gives 77 % of Area Under Curve(AUC), 83% of accuracy, 93% of specificity and 60% of sensitivity.