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Robustness to axon initial segment variation is explained by somatodendritic excitability in rat substantia nigra dopaminergic neurons
2019
Journal of Neuroscience
In many neuronal types, axon initial segment (AIS) geometry critically influences neuronal excitability. Interestingly, the axon of rat SNc dopaminergic (DA) neurons displays a highly variable location and most often arises from an axon-bearing dendrite (ABD). We combined current-clamp somatic and dendritic recordings, outside-out recordings of dendritic sodium and potassium currents, morphological reconstructions and multicompartment modeling on male and female rat SNc DA neurons to determine
doi:10.1523/jneurosci.2781-18.2019
pmid:31028116
pmcid:PMC6595954
fatcat:cgpzjtxvozfellzpbdl5ghpbsq