Synthesis and antibacterial activity of novel N -acylsulfonamides

Malika Berredjem, Fouzia Bouchareb, Samira Ait Kaki, Maazouz Dekhil, Nour-Eddine Aouf
2017 Arabian Journal of Chemistry  
A series of novel N-acylsulfonamide derivatives were synthesized and characterized by 1 H NMR, 13 C NMR and HRMS. The N-acylsulfonamides were prepared in four steps (carbamoylation, sulfamoylation, deprotection and acylation) starting from chlorosulfonyl isocyanate. These compounds were evaluated in vitro as antimicrobial agents against representative strains of Grampositive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Acinetobacter, Klebsiella pneumonia and Pseudomonas
more » ... seudomonas aeruginosa). ª 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
doi:10.1016/j.arabjc.2013.01.016 fatcat:uatumbhvhzfchk5ckbv6vha54e